A DOENÇA DE CROHN EM DECORRÊNCIA DA DESREGULAÇÃO DO SISTEMA IMUNOLÓGICO
DOI:
https://doi.org/10.47820/recima21.v3i8.1844Keywords:
''immune system'', ''crohn's disease''Abstract
Introduction: Crohn's disease (CD) is an incurable inflammatory bowel disease in which occurs inflammation and ulceration of the mucosa in the gastrointestinal tract. The lymphocytes of the immune system control the inflammatory process by causing an excessive increase in pro-inflammatory cytokines. Objective: To analyze the influence of the immune system on the origin and development of CD. Materials and Methods: An integrative literature review was performed, aiming to correlate the immune system with CD. For data analysis, clinical study, clinical trial, comparative study, meta-analysis, multicenter study, observational study, and randomized controlled trial were included. Articles from the Pubmed database, published between the years 2018 through 2022, were used for this study. The descriptors chosen were "crohn 's disease" and "immune system". Books and documents, reviews and systematic reviews were excluded. After inclusion and exclusion criteria, 28 articles were selected. Results: Cytokines and chemokines released from the increase of neutrophils will increase the severity of inflammation. In this process interleukin-1, interleukin-6 and tumor necrosis factor-α will be expressed. Conclusion: The immune system has a strong relation with the progression of CD from an imbalance in the production of defense cells, triggering immunological lesions and prominent infiltrations of these cells.
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