EVALUACIÓN DE LA EFICACIA DE LOS NUEVOS TRATAMIENTOS ANTICOAGULANTES ORALES EN LA PREVENCIÓN DE ACONTECIMIENTOS RELACIONADOS CON LA FIBRILACIÓN AURICULAR: REVISIÓN BIBLIOGRÁFICA

Autores/as

DOI:

https://doi.org/10.47820/recima21.v5i5.5203

Palabras clave:

Fibrilación auricular, nuevas terapias anticoagulantes orales, prevención de eventos cardiovasculares.

Resumen

Introducción: La fibrilación auricular es una condición clínica frecuente asociada a un aumento significativo del riesgo de eventos cardiovasculares, como el ictus. El advenimiento de nuevas terapias anticoagulantes orales, como los inhibidores directos del factor Xa y la trombina, ha traído nuevas perspectivas para el tratamiento y la prevención de estos eventos. Objetivo: Esta revisión bibliográfica tiene como objetivo evaluar la eficacia de las nuevas terapias anticoagulantes orales en la prevención de eventos cardiovasculares relacionados con la fibrilación auricular. Métodos: Esta revisión bibliográfica se realizó a través de una búsqueda sistemática de la literatura científica publicada en los últimos 15 años, abarcando el período de 2009 a 2024, utilizando las bases de datos PubMed, Web of Science, Scopus y Google Scholar. Se incluyeron estudios originales y revisiones que investigaran las características de las nuevas terapias anticoagulantes orales y su eficacia en la prevención de eventos cardiovasculares en pacientes con fibrilación auricular. Resultados y discusión: Los estudios revisados destacaron la eficacia de las nuevas terapias anticoagulantes orales en la reducción del riesgo de eventos cardiovasculares, como el accidente cerebrovascular, en comparación con la warfarina. Además, estos fármacos han mostrado un perfil de seguridad favorable, con una menor incidencia de hemorragia intracraneal. También se destacaron la adherencia y el cumplimiento del tratamiento como ventajas de las nuevas terapias, contribuyendo a una mejor calidad de vida de los pacientes. 

Descargas

Los datos de descarga aún no están disponibles.

Biografía del autor/a

  • Lucas Mainardo Rodrigues Bezerra

    Instituto de Educação Superior do Vale do Parnaíba-IESVAP.

  • Lívia Farias de Holanda Furtado

    Acadêmica de Medicina.

  • Vanessa Maria Lopes Vieira

    Academica de Medicina.

  • Luis Gabriel Campos Pires

    Acadêmico de Medicina.

  • Diana Sampaio Ericeira

    Acadêmica de Medicina.

  • Maycon Duarte Leite

    Acadêmico de Medicina.

  • César Furlan Ribeiro

    Acadêmico de Medicina.

  • Kaline dos Santos Kishishita Castro

    Acadêmica de Medicina.

  • Mariana Cordeiro de Souza

    Acadêmica de Medicina.

  • Elba Laiza Barroso Martins

    Acadêmica de Medicina.

Referencias

AMIN, Alpesh et al. Estimation of the impact of warfarin’s time-in-therapeutic range on stroke and major bleeding rates and its influence on the medical cost avoidance associated with novel oral anticoagulant use-learnings from ARISTOTLE, ROCKET-AF, and RE-LY trials. Journal of thrombosis and thrombolysis, v. 38, p. 150-159, 2014. DOI: https://doi.org/10.1007/s11239-013-1048-z

BANG, Oh Young et al. The risk of stroke/systemic embolism and major bleeding in Asian patients with non-valvular atrial fibrillation treated with non-vitamin K oral anticoagulants compared to warfarin: Results from a real-world data analysis. PLoS One, v. 15, n. 11, p. e0242922, 2020. DOI: https://doi.org/10.1371/journal.pone.0242922

CARDOSO, Rhanderson et al. Non-vitamin K antagonists versus warfarin in patients with atrial fibrillation and bioprosthetic valves: a systematic review and meta-analysis. The American Journal of Medicine, v. 135, n. 2, p. 228-234, e1, 2022. DOI: https://doi.org/10.1016/j.amjmed.2021.08.026

CINTRA, Fatima Dumas; FIGUEIREDO, Marcio Jansen de Oliveira. Fibrilação atrial (Parte 1): fisiopatologia, fatores de risco e bases terapêuticas. Arquivos Brasileiros de Cardiologia, v. 116, p. 129-139, 2021. DOI: https://doi.org/10.36660/abc.20200485

COSTELLO, M. et al. Effect of non‐vitamin‐K oral anticoagulants on stroke severity compared to warfarin: a meta‐analysis of randomized controlled trials. European journal of neurology, v. 27, n. 3, p. 413-418, 2020. DOI: https://doi.org/10.1111/ene.14134

DALIA, Adam A. et al. Anesthesiologists guide to the 2019 AHA/ACC/HRS focused update for the management of patients with atrial fibrillation. Journal of cardiothoracic and vascular anesthesia, v. 34, n. 7, p. 1925-1932, 2020. DOI: https://doi.org/10.1053/j.jvca.2019.08.046

DEMARIA, Anthony; COTTER, Bruno. Choosing between a NOAC or a vitamin K antagonist: an approach based on risk stratification. European Heart Journal, v. 38, n. 12, p. 897-898, 2017. DOI: https://doi.org/10.1093/eurheartj/ehw644

GELLER, Bram J. et al. Systemic, noncerebral, arterial embolism in 21,105 patients with atrial fibrillation randomized to edoxaban or warfarin: results from the Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction Study 48 trial. American Heart Journal, v. 170, n. 4, p. 669-674, 2015. DOI: https://doi.org/10.1016/j.ahj.2015.06.020

HE, Qiyu et al. Comparing clinical outcomes of NOACs with warfarin on atrial fibrillation with valvular heart diseases: a meta-analysis. BMC Cardiovascular Disorders, v. 19, p. 1-13, 2019. DOI: https://doi.org/10.1186/s12872-019-1089-0

HEO, MuHyung et al. Comparison of Early Complications of Oral Anticoagulants after Totally Thoracoscopic Ablation: Warfarin versus Non-vitamin K Antagonist Oral Anticoagulants. Journal of Chest Surgery, v. 56, n. 2, p. 90, 2023. DOI: https://doi.org/10.5090/jcs.22.081

HU, Jingjing; ZHOU, Yidan; CAI, Zhaobin. Outcome of novel oral anticoagulant versus warfarin in frail elderly patients with atrial fibrillation: a systematic review and meta-analysis of retrospective studies. Acta Clinica Belgica, v. 78, n. 5, p. 367-377, 2023. DOI: https://doi.org/10.1080/17843286.2023.2179908

JANUARY, Craig T. et al. 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the Heart Rhythm Society. Circulation, v. 130, n. 23, p. 2071-2104, 2014. DOI: https://doi.org/10.1161/CIR.0000000000000040

JONES, Daniel A. et al. The use of novel oral anticoagulants compared to vitamin K antagonists (warfarin) in patients with left ventricular thrombus after acute myocardial infarction. European Heart Journal-Cardiovascular Pharmacotherapy, v. 7, n. 5, p. 398-404, 2021. DOI: https://doi.org/10.1093/ehjcvp/pvaa096

JUSTO, Fernanda Augusto; SILVA, Ana Flávia Garcia. Aspectos epidemiológicos da fibrilação atrial. Revista de Medicina, v. 93, n. 1, p. 1-13, 2014. DOI: https://doi.org/10.11606/issn.1679-9836.v93i1p1-13

KUMBHANI, Dharam J. et al. Caminho de decisão de consenso de especialistas do ACC 2020 para terapia anticoagulante e antiplaquetária em pacientes com fibrilação atrial ou tromboembolismo venoso submetidos a intervenção coronária percutânea ou com doença cardiovascular aterosclerótica: um relatório do Comitê de Supervisão do Conjunto de Soluções do American College of Cardiology. Jornal do Colégio Americano de Cardiologia, v. 77, n. 5, pág. 629-658, 2021.

KUNDU, Amartya et al. Minimizing the risk of bleeding with NOACs in the elderly. Drugs & aging, v. 33, p. 491-500, 2016. DOI: https://doi.org/10.1007/s40266-016-0376-z

LIMA, Paula Rocco Gomes et al. Fatores relacionados à adesão de pacientes ao uso de novos anticoagulantes orais. Revista da Escola de Enfermagem da USP, v. 56, p. e20210191, 2021. DOI: https://doi.org/10.5935/978-65-5848-242-0.C0005

LIP, Gregory Y. H. et al. Effectiveness and safety of oral anticoagulants among nonvalvular atrial fibrillation patients: the ARISTOPHANES study. Stroke, v. 49, n. 12, p. 2933-2944, 2018. DOI: https://doi.org/10.1161/STROKEAHA.118.020232

MELGAARD, Line et al. Effectiveness and safety of NOAC versus warfarin in patients with atrial fibrillation and aortic stenosis. Journal of the American Heart Association, v. 10, n. 23, p. e022628, 2021. DOI: https://doi.org/10.1161/JAHA.121.022628

MIHAILA, Romeo Gabriel. Warfarin involvement, in comparison to NOACs, in the development of systemic atherosclerosis. Biomedical Papers of the Medical Faculty of Palacky University in Olomouc, v. 166, n. 2, 2022. DOI: https://doi.org/10.5507/bp.2022.008

NAM, Ki-Woong et al. Effectiveness and safety of secondary prevention of non-vitamin K oral anticoagulants use by drug type in Asian patients. International Journal of Stroke, v. 18, n. 8, p. 927-936, 2023. DOI: https://doi.org/10.1177/17474930231176715

NEPAL, Gaurav et al. Safety and efficacy of Direct Oral Anticoagulants in cerebral venous thrombosis: A meta‐analysis. Acta Neurologica Scandinavica, v. 145, n. 1, p. 10-23, 2022. DOI: https://doi.org/10.1111/ane.13506

OSHO, Asishana A. et al. Rationale and Design of the Randomized Controlled Trial of New Oral Anticoagulants Versus Warfarin for Post Cardiac Surgery Atrial Fibrillation: The NEW-AF Trial. Annals of Surgery, v. 276, n. 1, p. 200-204, 2022. DOI: https://doi.org/10.1097/SLA.0000000000004459

PATEL, Priya et al. NOACs vs. warfarin for stroke prevention in nonvalvular atrial fibrillation. Cureus, v. 9, n. 6, 2017. DOI: https://doi.org/10.7759/cureus.1395

PIEPIORKA-BRONIECKA, Marta et al. NOAC versus warfarin in the treatment of atrial fibrillation during the first three months after bioprosthetic aortic valve replacement. Cardiology Journal, v. 29, n. 2, p. 355-357, 2022. DOI: https://doi.org/10.5603/CJ.a2021.0158

SCHÄFER, Andreas et al. Anticoagulants for stroke prevention in atrial fibrillation in elderly patients. Cardiovascular drugs and therapy, v. 34, p. 555-568, 2020. DOI: https://doi.org/10.1007/s10557-020-06981-3

SENOO, Keitaro et al. Efficacy and safety of non-vitamin K antagonist oral anticoagulants vs. warfarin in Japanese patients with atrial fibrillation–meta-analysis. Circulation Journal, v. 79, n. 2, p. 339-345, 2015. DOI: https://doi.org/10.1253/circj.CJ-14-1042

STERNE, Jonathan AC et al. Oral anticoagulants for primary prevention, treatment and secondary prevention of venous thromboembolic disease, and for prevention of stroke in atrial fibrillation: systematic review, network meta-analysis and cost-effectiveness analysis. Health Technology Assessment, v. 21, n. 9, 2017. DOI: https://doi.org/10.3310/hta21090

SVENSSON, Peter J.; SJÄLANDER, Anders. NOAC in everyday clinical practice. Lakartidningen, v. 112, p. DH3X-DH3X, 2015.

VERDECCHIA, Paolo et al. Why switch from warfarin to NOACs?. Internal and emergency medicine, v. 11, p. 289-293, 2016. DOI: https://doi.org/10.1007/s11739-016-1411-0

VIRANI, Salim S. et al. "Heart disease and stroke statistics—2020 update: a report from the American Heart Association." Circulation, v. 141, n. 9, p. e139-e596, 2020.

WANG, Xinyi et al. Efficacy and Safety of Oral Anticoagulants in Older Adult Patients with Atrial Fibrillation: Pairwise and Network Meta-Analyses. Journal of the American Medical Directors Association, 2023. DOI: https://doi.org/10.1016/j.jamda.2023.05.010

WU, Victor Chien-Chia et al. Efficacy and safety of NOAC versus warfarin in AF patients with left atrial enlargement. Plos one, v. 15, n. 12, p. e0243866, 2020. DOI: https://doi.org/10.1371/journal.pone.0243866

YAO, Xiaoxi et al. Renal outcomes in anticoagulated patients with atrial fibrillation. Journal of the American College of Cardiology, v. 70, n. 21, p. 2621-2632, 2017. DOI: https://doi.org/10.1016/j.jacc.2017.09.1087

Publicado

09/05/2024

Cómo citar

EVALUACIÓN DE LA EFICACIA DE LOS NUEVOS TRATAMIENTOS ANTICOAGULANTES ORALES EN LA PREVENCIÓN DE ACONTECIMIENTOS RELACIONADOS CON LA FIBRILACIÓN AURICULAR: REVISIÓN BIBLIOGRÁFICA. (2024). RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218, 5(5), e555203. https://doi.org/10.47820/recima21.v5i5.5203