LO QUE EL AYUNO INTERMITENTE TIENE QUE DECIR SOBRE EL CÁNCER, LA SALUD CARDIOVASCULAR Y LA SALUD MENTAL DEL CEREBRO
DOI:
https://doi.org/10.47820/recima21.v4i1.2638Palabras clave:
ayuno intermitente es una estrategia nutricional en la que se intercalan períodos de ayunoResumen
INTRODUCCIÓN: El ayuno intermitente es una estrategia nutricional en la que se intercalan períodos de ayuno con períodos de alimentación dirigidos a la promoción de la salud. El presente estudio investiga si esta práctica promueve efectos beneficiosos sobre el tratamiento cardiovascular, la salud mental cerebral y el cáncer. MÉTODOS: Los datos fueron recolectados a partir de la búsqueda en bases de datos electrónicas. Se utilizaron los descriptores: Ayuno intermitente; disfunción cognitiva; Cáncer. Se seleccionaron revistas de una categoría superior a B3, utilizando como criterios los artículos enviados entre 2016 y 2019. Como criterios de exclusión, se excluyeron del análisis los artículos que no presentaron un resultado con ayuno intermitente o que utilizaron animales distintos de ratones o humanos. RESULTADOS: El ayuno intermitente demostró ser un aliado eficiente en el tratamiento contra el cáncer debido a su efecto potenciador sobre el tratamiento de quimioterapia, reduciendo el progreso de la enfermedad, además, se observó una reducción en los parámetros de riesgo cardiovascular en individuos bajo restricción calórica al mismo tiempo que se observó mejoría en el rendimiento cognitivo. CONCLUSIÓN: En conclusión, el ayuno intermitente demostró ser un aliado eficaz en el tratamiento del cáncer al ralentizar su progresión, así como en la promoción de la salud a partir de ganancias en la salud cardiovascular y mental-cerebral.
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AMARAVADI, Ravi; KIMMELMAN, Alec C.; WHITE, Eileen. Recent insights into the function of autophagy in cancer. Genes & Development. [s.l.], v.30, n.17, p. 1913-1930, Set/Set. 2016.
ANTONI, Rona et al. Effects of intermittent fasting on glucose and lipid metabolism. Proceedings Of The Nutrition Society. Cambridge, v.76, n.3, p. 361-368, Jan/Ago. 2017.
ANTONI, Rona et al. Investigation into the acute effects of total and partial energy restriction on postprandial metabolism among overweight/obese participants. British Journal Of Nutrition. [s.l.], v.115, n.6, p. 951-959, Mar. 2016.
ANTUNES, Fernanda et al. Autophagy and intermittent fasting: the connection for cancer therapy?. Clinics. São Paulo, v.73, n. supl 1, p. e814s, Mai/Set. 2018.
BOUTANT, Marie et al. SIRT1 Gain of Function Does Not Mimic or Enhance the Adaptations to Intermittent Fasting. Cell Reports. [s.l.], v.14, n.9, p. 2068-2075, Mar. 2016.
CATENACCI, Victoria A. et al. A randomized pilot study comparing zero-calorie alternate-day fasting to daily caloric restriction in adults with obesity. Obesity (silver Spring). [s.l.], v.24, n.9, p. 1874-1883, Set. 2016.
CHENG, Aiwu et al. Mitochondrial SIRT3 Mediates Adaptive Responses of Neurons to Exercise, and Metabolic and Excitatory Challenges. Cell Metabolism. [s.l.], v.23, n.1, p. 128-142, Jan. 2016.
CIGNARELLA, Francesca et al. Intermittent Fasting Confers Protection in CNS Autoimmunity by Altering the Gut Microbiota. Cell Metabolism. [s.l.], v.27, n.6, p. 1222-1235, Jan. 2018.
CORLEY, B. T. et al. Intermittent fasting in Type 2 diabetes mellitus and the risk of hypoglycaemia: a randomized controlled trial. Diabetic Medicine. Wellington, v.35, n.5, p. 588-594, Jan/Mai. 2018.
DORFF, Tanya B. et al. Safety and feasibility of fasting in combination with platinum-based chemotherapy. Bmc Cancer. [s.l.], v.16, n.360, p. 1-9, Jun. 2016.
FANN, David Yang-wei et al. Positive effects of intermittent fasting in ischemic stroke. Experimental Gerontology. Singapura, v.89, p. 93-102, Mar. 2017.
FASSIER, Philippine et al. Fasting and weight-loss restrictive diet practices among 2,700 cancer survivors: results from the NutriNet-Santé cohort. International Journal Of Cancer. Bobigny, France, v.143, n.11, p. 2687-2697, Jul/Dez. 2018.
FASSIER, Philippine et al. Sociodemographic and economic factors are associated with weight gain between before and after cancer diagnosis: results from the prospective population-based NutriNet-Santé cohort. Oncotarget. Bobigny, France, v.8, n.33, p. 54640-54653, Nov/Mai. 2017.
GALLUZZI, Lorenzo et al. Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nature Reviews Drug Discovery. [s.l.], v.16, n.7, p. 487-511, Mai/Jul. 2017.
GIGLI, Rafael et al. The biphosphinic paladacycle complex induces melanoma cell death through lysosomal–mitochondrial axis modulation and impaired autophagy. European Journal Of Medicinal Chemistry. [s.l.], v.107, p. 245-254, Jan/Jan. 2016.
GRASSO, Silvina et al. Autophagy regulates Selumetinib (AZD6244) induced-apoptosis in colorectal cancer cells. European Journal Of Medicinal Chemistry. [s.l.], v.122, p. 611-618, Out. 2016.
GOTTHARDT, Juliet D. et al. Intermittent Fasting Promotes Fat Loss With Lean Mass Retention, Increased Hypothalamic Norepinephrine Content, and Increased Neuropeptide Y Gene Expression in Diet-Induced Obese Male Mice. Endocrinology. [s.l.], v.157, n.2, p. 679-691, Fev. 2016.
HARVIE, Michelle N; HOWELL, Tony. Could Intermittent Energy Restriction and Intermittent Fasting Reduce Rates of Cancer in Obese, Overweight, and Normal-Weight Subjects? A Summary of Evidence. Advances In Nutrition. [s.l.], v.7, n.4, p. 690-705, Jul. 2016.
HARVIE, Michelle N. et al. Intermittent energy restriction induces changes in breast gene expression and systemic metabolism. Breast Cancer Research. [s.l.], v.18, n.1, p. 57, Mai. 2016.
JOSLIN, P. M. N.; BELL, R. K.; SWOAP, S. J.. Obese mice on a high-fat alternate-day fasting regimen lose weight and improve glucose tolerance. Journal Of Animal Physiology And Animal Nutrition (Berl). [s.l.], v.101, n.5, p. 1036-1045, Out. 2017.
KIM, Kyoung-han et al. Intermittent fasting promotes adipose thermogenesis and metabolic homeostasis via VEGF-mediated alternative activation of macrophage. Cell Research. [s.l.], v.27, n.11, p. 1309-1326, Nov. 2017.
LEVY, Jean M. Mulcahy; TOWERS, Christina G.; THORBURN, Andrew. Targeting autophagy in cancer. Nature Reviews Cancer. [s.l.], v.17, n.9, p. 528-542, Jul. 2017.
LI, Guolin et al. Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota. Cell Metabolism. [s.l.], v.26, n.4, p. 672-685, Out. 2017.
LIU, Xiangyu et al. Inhibition of Autophagy by Chloroquine Enhances the Antitumor Efficacy of Sorafenib in Glioblastoma. Cellular And Molecular Neurobiology. [s.l.], v.36, p. 1197-1208, Mar/Out. 2016.
LIU, Bo et al. Intermittent fasting increases energy expenditure and promotes adipose tissue browning in mice. Nutrition. Adelaide, v.66, p. 38-43, Dez/Out. 2019.
MARTEL, Cécile et al. Knockdown of angiopoietin-like 2 mimics the benefits of intermittent fasting on insulin responsiveness and weight loss. Experimental Biology And Medicine. Montreal, v.243, p. 45-49, Set/Nov. 2018.
MATTSON, Mark P.; LONGO, Valter D.; HARVIED, Michelle. Impact of intermittent fasting on health and disease processes. Ageing Research Reviews. [s.l.], v.39, p. 46-58, Out. 2017.
MORO, Tatiana et al. Effects of eight weeks of time-restricted feeding (16/8) on basal metabolism, maximal strength, body composition, inflammation, and cardiovascular risk factors in resistance-trained males. Journal Of Translational Medicine. [s.l.], v.14, n.1, p. 290, Out. 2016.
O’FLANAGAN, Ciara H. et al. When less may be more: calorie restriction and response to cancer therapy. Bmc Medicine. [s.l.], v.15, n.1, p. 1-9, Mai. 2017.
PATTERSON, Ruth e; DOROTHY, D Sears. Metabolic Effects of Intermittent Fasting. Annual review of nutrition vol. 37 (2017): 371-393.
PIETROCOLA, Federico et al. Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance. Cancer Cell. [s.l.], v.30, n.1, p. 147-160, Jul. 2016.
POTTER, Gregory D M et al. Nutrition and the circadian system. British Journal Of Nutrition. [s.l.], v.116, n.3, p. 434-442, Ago. 2016.
RE, Oriana Lo et al. Fasting inhibits hepatic stellate cells activation and potentiates anti‐cancer activity of Sorafenib in hepatocellular cancer cells. Journal Of Cellular Physiology. [s.l.], v.233, n.2, p. 1202-1212, Fev. 2018.
SHARIFI, Marina N. et al. Autophagy Promotes Focal Adhesion Disassembly and Cell Motility of Metastatic Tumor Cells through the Direct Interaction of Paxillin with LC3. Cell Reports. [s.l.], v.15, n.8, p. 1660-1672, Mai. 2016.
SHIN, Bae Kun et al. Intermittent fasting protects against the deterioration of cognitive function, energy metabolism and dyslipidemia in Alzheimer’s disease-induced estrogen deficient rats. Experimental Biology And Medicine. Asan, v.243, p. 334-343, Set/Dez. 2018.
ST-ONGE, Marie-pierre et al. Meal Timing and Frequency: Implications for Cardiovascular Disease Prevention: A Scientific Statement From the American Heart Association. Circulation. [s.l.], v.135, n.9, p. e96-e121, Fev. 2017.
SILVA LIMA, C. L.; SALMITO, P. A.; ARAÚJO, L. DA S.; LIRA, S. M.; DA SILVA, J. Y. G.; HOLANDA, M. O.; PAIM, R. T. T.; GIRÃO, N. M. Jejum intermitente no emagrecimento: uma revisão sistemática. RBNE - Revista Brasileira de Nutrição Esportiva, v. 13, n. 79, p. 426-436, 9 set. 2019.
SUN, Pengfei et al. Fasting inhibits colorectal cancer growth by reducing M2 polarization of tumor-associated macrophages. Oncotarget. [s.l.], v.8, n.43, p. 74649-74660, Mai/Ago. 2017.
TREPANOWSKI, John F; BLOOMER, Richard J. The impact of religious fasting on human health. Nutrition journal v. 9 n.57. Nov. 2010.
TINSLEY, Grant M.; HORNE, Benjamin D.. Intermittent fasting and cardiovascular disease: current evidence and unresolved questions. Future Cardiol. [s.l.], v.14, n.1, p. 47-54, Abr/Dez. 2017.
TINSLEY, Grant M. et al. Time-restricted feeding in young men performing resistance training: A randomized controlled trial. European Journal Of Sport Science. [s.l.], v.17, n.2, p. 200-207, Mar. 2017.
XIE, K., et al. Every-other-day feeding extends lifes pan but fails to delay many symptoms of aging in mice. Nature Communications. [s.l.], v.8, n.1, p. 155, Jul. 2017.
YANG, Wanwei et al. Alternate-day fasting protects the livers of mice against high-fat diet-induced inflammation associated with the suppression of Toll-like receptor 4/nuclear factor κB signaling. Nutrition Research. [s.l.], v.36, n.6, p. 586-593, Jun. 2016.
ZUO, Li et al. Comparison of High-Protein, Intermittent Fasting Low-Calorie Diet and Heart Healthy Diet for Vascular Health of the Obese. Frontiers In Physiology. [s.l.], v.7, p. 350, Ago. 2016.
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