DEFICIENCIA DE VITAMINA B12 POR EL USO DE METFORMINA EN PACIENTES CON DIABETES MELLITUS TIPO 2
DOI:
https://doi.org/10.47820/recima21.v5i10.5724Palabras clave:
Vitamina B12; Metformina; Diabetes.Resumen
El uso prolongado de metformina, un tratamiento común para la DM2, se asocia con deficiencia de vitamina B12, requiriendo un control regular de los niveles de vitamina en los pacientes tratados. Material y Métodos: Se trata de una revisión integradora de la literatura sobre la deficiencia de vitamina B12 inducida por metformina en pacientes con diabetes tipo 2, utilizando artículos de PubMed de 2019 a 2024, con estrictos criterios de inclusión y exclusión. Resultado y discusión: La metformina se asocia con la deficiencia de vitamina B12, lo que afecta la absorción intestinal de la vitamina, lo que puede provocar complicaciones como neuropatía y anemia. Estudios demuestran que el uso prolongado y en dosis altas aumenta el riesgo de deficiencia de B12 en pacientes con diabetes tipo 2. Conclusión: El uso de metformina está relacionado con la deficiencia de vitamina B12, afectando la absorción de la vitamina y provocando complicaciones como neuropatía y anemia. pacientes con diabetes tipo 2, especialmente en dosis altas y tratamientos prolongados.
Descargas
Citas
AHMED, Marwan A. et al. Perspectives on peripheral neuropathy as a consequence of metformin-induced vitamin B12 deficiency in T2DM. International Journal of Endocrinology, v. 2017, 2017. DOI: https://doi.org/10.1155/2017/2452853
AL QURAN, Thekraiat et al. Prevalence of vitamin B12 deficiency in type 2 diabetic patients taking metformin, a cross-sectional study in primary healthcare. Frontiers in Endocrinology, v. 14, p. 1226798, 2023. DOI: https://doi.org/10.3389/fendo.2023.1226798
AL SAEED, Roqaih R.; BARAJA, Muneera A. Vitamin B12 deficiency in patients with type 2 diabetes mellitus using metformin and the associated factors in Saudi Arabia. Saudi medical journal, v. 42, n. 2, p. 161, 2021. DOI: https://doi.org/10.15537/smj.2021.2.25693
AL-FAWAEIR, Saad; AL-ODAT, Ibrahim. Influence of metformin intake on serum vitamin B12 levels in patients with type 2 diabetes mellitus. Plos one, v. 17, n. 12, p. e0279740, 2022. DOI: https://doi.org/10.1371/journal.pone.0279740
ALHAJI, Jwaher Haji. Vitamin B12 deficiency in patients with diabetes on metformin: Arab countries. Nutrients, v. 14, n. 10, p. 2046, 2022. DOI: https://doi.org/10.3390/nu14102046
AL-HAMDI, Ahmed et al. Vitamin B12 deficiency in diabetic patients on metformin therapy: a cross-sectional study from Oman. Sultan Qaboos University Medical Journal, v. 20, n. 1, p. e90, 2020. DOI: https://doi.org/10.18295/squmj.2020.20.01.013
ALVAREZ, Mauricio et al. Vitamin B12 deficiency and diabetic neuropathy in patients taking metformin: a cross-sectional study. Endocrine connections, v. 8, n. 10, p. 1324-1329, 2019. DOI: https://doi.org/10.1530/EC-19-0382
BAIG, Fraz Ahmed; KHAN, Saad; RIZWAN, Amber. Frequency of vitamin B12 deficiency in type 2 diabetic patients taking metformin. Cureus, v. 14, n. 3, 2022. DOI: https://doi.org/10.7759/cureus.22924
DE SOUSA, Luís Manuel Mota et al. A metodologia de revisão integrativa da literatura em enfermagem. Revista investigação em enfermagem, v. 21, n. 2, p. 17-26, 2017.
ERCOLE, Flávia Falci; MELO, Laís Samara de; ALCOFORADO, Carla Lúcia Goulart Constant. Revisão integrativa versus revisão sistemática. Reme: Revista Mineira de Enfermagem, v. 18, n. 1, p. 09-11, 2014. DOI: https://doi.org/10.5935/1415-2762.20140001
FITURI, Sundus; AKBAR, Zoha; GANJI, Vijay. Impact of metformin treatment on cobalamin status in persons with type 2 diabetes. Nutrition Reviews, v. 82, n. 4, p. 553-560, 2024. DOI: https://doi.org/10.1093/nutrit/nuad045
GAO, Leili et al. The effects of daily dose and treatment duration of metformin on the prevalence of vitamin B12 deficiency and peripheral neuropathy in Chinese patients with type 2 diabetes mellitus: A multicenter cross-sectional study. Journal of diabetes, v. 15, n. 9, p. 765-776, 2023. DOI: https://doi.org/10.1111/1753-0407.13428
GREEN, Ralph et al. Vitamin B12 deficiency. Nature reviews Disease primers, v. 3, n. 1, p. 1-20, 2017. DOI: https://doi.org/10.1038/nrdp.2017.40
HURLEY-KIM, Keri et al. Effect of metformin use on vitamin B12 deficiency over time (EMBER): a real-world evidence database study. Endocrine Practice, v. 29, n. 11, p. 862-867, 2023. DOI: https://doi.org/10.1016/j.eprac.2023.06.013
HUYNH, Dat Tan; NGUYEN, Ngoc Thi; DO, Minh Duc. Vitamin B12 deficiency in diabetic patients treated with metformin: A cross-sectional study. Plos one, v. 19, n. 4, 2024. DOI: https://doi.org/10.1371/journal.pone.0302500
INFANTE, Marco et al. Long-term metformin therapy and vitamin B12 deficiency: an association to bear in mind. World journal of diabetes, v. 12, n. 7, p. 916, 2021. DOI: https://doi.org/10.4239/wjd.v12.i7.916
KAKARLAPUDI, Yasitha et al. Effect of metformin on vitamin B12 deficiency in patients with type 2 diabetes mellitus and factors associated with it: a meta-analysis. Cureus, v. 14, n. 12, 2022. DOI: https://doi.org/10.7759/cureus.32277
MENDES, Karina Dal Sasso; SILVEIRA, Renata Cristina de Campos Pereira; GALVÃO, Cristina Maria. Revisão integrativa: método de pesquisa para a incorporação de evidências na saúde e na enfermagem. Texto & contexto-enfermagem, v. 17, p. 758-764, 2008. DOI: https://doi.org/10.1590/S0104-07072008000400018
MIYAN, Zahid; WARIS, Nazish. Association of vitamin B12 deficiency in people with type 2 diabetes on metformin and without metformin: a multicenter study, Karachi, Pakistan. BMJ Open Diabetes Research and Care, v. 8, n. 1, p. e001151, 2020. DOI: https://doi.org/10.1136/bmjdrc-2019-001151
PYRGIOTI, Elisavet E.; KARAKOUSIS, Nikolaos D. B12 levels and frailty syndrome. Journal of Frailty, Sarcopenia and Falls, v. 7, n. 1, p. 32, 2022. DOI: https://doi.org/10.22540/JFSF-07-032
ROJBI, Imen et al. Vitamin B12 levels in type 2 diabetic patients on Metformin compared to those never on Metformin: a cross sectional study in Tunisia. La Tunisie Medicale, v. 101, n. 4, p. 433-439, 2023.
SAYEDALI, Ehsan; YALIN, Ali Erdinç; YALIN, Serap. Association between metformin and vitamin B12 deficiency in patients with type 2 diabetes. World journal of diabetes, v. 14, n. 5, p. 585, 2023. DOI: https://doi.org/10.4239/wjd.v14.i5.585
SUGAWARA, Kenji et al. Relationship between metformin use and vitamin B12 status in patients with type 2 diabetes in Japan. Journal of diabetes investigation, v. 11, n. 4, p. 917-922, 2020. DOI: https://doi.org/10.1111/jdi.13200
THEWJITCHAROEN, Yotsapon et al. Metformin-Associated Vitamin B12 Deficiency: An Underrecognized Complication. JCEM Case Reports, v. 2, n. 4, p. luae029, 2024. DOI: https://doi.org/10.1210/jcemcr/luae029
TIWARI, Aakriti et al. Metformin-Induced Vitamin B12 Deficiency in Patients With Type-2 Diabetes Mellitus. Cureus, v. 15, n. 10, 2023. DOI: https://doi.org/10.7759/cureus.47771
TOMKIN, G. H. et al. Vitamin-B12 status of patients on long-term metformin therapy. Br Med J, v. 2, n. 5763, p. 685-687, 1971. DOI: https://doi.org/10.1136/bmj.2.5763.685
TORREZ, Mary et al. How I investigate acquired megaloblastic anemia. International journal of laboratory hematology, v. 44, n. 2, p. 236-247, 2022. DOI: https://doi.org/10.1111/ijlh.13789
WOLFFENBUTTEL, Bruce HR et al. The many faces of cobalamin (vitamin B12) deficiency. Mayo clinic proceedings: innovations, quality & outcomes, v. 3, n. 2, p. 200-214, 2019. DOI: https://doi.org/10.1016/j.mayocpiqo.2019.03.002
YADAV, Anil et al. Vitamin B12 Deficiency among Metformin Treated Type 2 Diabetic Mellitus Patients Visiting the Department of Medicine of a Tertiary Care Centre. JNMA: Journal of the Nepal Medical Association, v. 61, n. 267, p. 861, 2023. DOI: https://doi.org/10.31729/jnma.8340
Descargas
Publicado
Cómo citar
Número
Sección
Categorías
Licencia
Derechos de autor 2024 RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218
Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
Os direitos autorais dos artigos/resenhas/TCCs publicados pertecem à revista RECIMA21, e seguem o padrão Creative Commons (CC BY 4.0), permitindo a cópia ou reprodução, desde que cite a fonte e respeite os direitos dos autores e contenham menção aos mesmos nos créditos. Toda e qualquer obra publicada na revista, seu conteúdo é de responsabilidade dos autores, cabendo a RECIMA21 apenas ser o veículo de divulgação, seguindo os padrões nacionais e internacionais de publicação.
