SCAFFOLDS MAGNÉTICOS DE QUITOSANA E/OU HIDROXIAPATITA PARA REGENERAÇÃO DE TECIDO ÓSSEO: UMA REVISÃO SISTEMÁTICA
DOI:
https://doi.org/10.47820/recima21.v4i3.2936Palavras-chave:
Scaffolds magnéticos. Quitosana. Hidroxiapatita. Regeneração Óssea.Resumo
A incorporação e a exploração de partículas com propriedades magnéticas como um potencializador dos processos de regeneração óssea por meio de scaffolds tridimensionais tem sido uma estratégia na engenharia de tecido ósseo, o que possibilita obtenção de estruturas com capacidade responsiva à estimulos externos, inteligentes e bioativos. Nesse sentido, este artigo propõe uma revisão sistemática baseada em artigos de pesquisa primária com foco em scaffolds magnéticos de quitosana e/ou hidroxiapatita na regeneração do tecido ósseo. Com este fim foi realizada uma busca nas plataformas Science Direct, Pubmed e Web of Science no período entre 2020 a 2022 e a revisão foi conduzida por meio do software Start. Critérios de inclusão foram utilizados para a seleção dos periódicos mais relevantes e observou-se que dentre as estratégias de scaffolds magnéticos de quitosana e/ou hidroxiapatita reportadas, as mais significativas envolveram indução da osteogenese endocondral, aumento nas vias de formação de vasos sanguíneos no tecido ósseo lesado, sistema de liberação de fármaco, entrega de fatores de crescimento e combate de células tumorais. Os resultados demonstraram esses sistemas apresentam potencial promissor de aplicação em regeneração óssea.
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