THE USE OF CARBETOCIN IN THE PREVENTION OF POSTPARTUM HEMORRHAGE: A LITERATURE REVIEW
DOI:
https://doi.org/10.47820/recima21.v5i8.5579Keywords:
Carbetocin. Postpartum hemorrhage. Clinical management.Abstract
Postpartum hemorrhage (PPH) is one of the leading causes of global maternal mortality, affecting approximately 5% of births. This condition is often caused by uterine atony, responsible for about 70% of cases, and is exacerbated by risk factors such as episiotomy and general anesthesia. The administration of effective uterotonics, such as oxytocin and carbetocin, plays a crucial role in reducing the risk of PPH, demonstrating a documented decrease of up to 66%. To investigate the efficacy of carbetocin in preventing PPH, 19 studies published from 2019 onwards were selected based on strictly relevant inclusion criteria. These studies highlighted carbetocin due to its superior thermal stability and comparative efficacy against other available uterotonics. Despite higher costs, its use potentially reduces significant obstetric complications and associated maternal health costs. Discussions emphasized the safety, efficacy, and feasibility of carbetocin in settings with logistical limitations, demonstrating its superior performance over oxytocin in various reviewed analyses. Despite economic challenges, cost-effectiveness studies supported its application, especially in high-risk deliveries and cesarean sections. Carbetocin stands out as a viable option, despite cost being a challenge, recommending its implementation in specific scenarios to improve obstetric outcomes and mitigate maternal mortality.
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