CIRCADIAN SLEEP REGULATION THROUGH MELATONIN SUPPLEMENTATION AND IMPACT ON CLINICAL MANAGEMENT OF WEIGHT EXCESS
DOI:
https://doi.org/10.47820/recima21.v3i1.1022Keywords:
Adiposity, Sleep hygiene, Melatonin, NutraceuticalsAbstract
The modern world has been associated, among other factors, with decreased sleep time and increased body fat. Sleep regulation is given by the action of the circadian system, regulated by the suprachiasmatic nucleus, which coordinates all metabolic and behavioral activities of individuals during the 24-hour period, including the secretion and action of melatonin, which acts as a chronobiotic, which , when out of balance, impacts on metabolic changes and eating behavior. The study aims to evaluate the effectiveness of melatonin supplementation as an adjuvant in the clinical treatment of obesity. This is a narrative bibliographic review, where data collection took place through Pubmed, Scielo and LILACS databases. Articles dated in the last 5 years were included, as well as information collected from the Brazilian Guidelines on Obesity (2016) and government websites such as the Ministry of Health and IBGE. Used the following DeCS: melatonin; nutrition; obesity; chrononutrition, in Portuguese and English. Melatonin has receptors in the peripheral adipose tissue, which results in its influence on the lipogenesis and lipolysis process, impacting the control of body weight. The action of exogenous melatonin on brown adipose tissue favors its hypertrophy, impacting thermogenesis regulation and balanced energy balance. Thus, its supplementation can be seen as an adjuvant therapy in the control of excess weight, as it favors the quality of sleep, resulting in reduced feeding time, control of the dietary circadian rhythm and management of insulin resistance in patients with excess body fat.
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References
Associação Brasileira para o Estudo da Obesidade e Síndrome Metabólica - ABESO. Diretriz Brasileira de Obesidade, 4.ed, São Paulo, SP., 2016.
World Health Organization. Obesity : preventing and managing the global epidemic : report of a WHO consultation. World Health Organization; 2000. 253 p.
Instituto Brasileiro de Geografia e Estatística (IBGE). Pesquisa Nacional de Saúde (PNS) 2019: Avaliação primária à saúde e informações antropométricas. Rio de Janeiro: IBGE; 2020.
Instituto Brasileiro de Geografia e Estatística (IBGE). Pesquisa de orçamentos familiares (POF) 2017-2018: Avaliação nutricional da disponibilidade domiciliar de alimentos no Brasil. Rio de Janeiro: IBGE; 2020.
Hall KD, Ayuketah A, Brychta R, Cai H, Cassimatis T, Chen KY, et al. Ultra-Processed Diets Cause Excess Calorie Intake and Weight Gain: An Inpatient Randomized Controlled Trial of Ad Libitum Food Intake. Cell Metab [Internet]. 2019 Jul 2;30(1):67-77.e3. Disponível em: https://doi.org/10.1016/j.cmet.2019.05.008
St-Onge M-P. Sleep-obesity relation: underlying mechanisms and consequences for treatment. Obes Rev [Internet]. 2017 Feb 1;18:34–9. Disponível em: http://doi.wiley.com/10.1111/obr.12499
Poggiogalle E, Jamshed H, Peterson CM. Circadian regulation of glucose, lipid, and energy metabolism in humans. Metabolism [Internet]. 2018 Jul 1;84:11–27. Disponível em: https://doi.org/10.1016/j.metabol.2017.11.017
Lunsford-Avery JR, Engelhard MM, Navar AM, Kollins SH. Validation of the Sleep Regularity Index in Older Adults and Associations with Cardiometabolic Risk. Sci Rep [Internet]. 2018 Dec 21;8(1):14158. Disponível em: https://doi.org/10.1038/s41598-018-32402-5
Xie Z, Chen F, Li WA, Geng X, Li C, Meng X, et al. A review of sleep disorders and melatonin. Neurol Res [Internet]. 2017 Jun 3;39(6):559–65. Disponível em: https://doi.org/10.1080/01616412.2017.1315864
Posicionamento da SBEM sobre a melatonina [Internet]. Disponível em: https://www.endocrino.org.br/media/uploads/PDFs/posicionamento_sobre_melatonina_sbem.pdf
Lucena JMS de, Cheng LA, Cavalcante TLM, Silva VA da, Farias Júnior JC de. Prevalência de tempo excessivo de tela e fatores associados em adolescentes. Rev Paul Pediatr [Internet]. 2015 Dec 1;33(4):407–14. Disponível em: https://doi.org/10.1016/j.rpped.2015.04.00
The importance of sleep in the various phases of life: a review of the literature. Revista Brasileira de Neurologia e Psiquiatria. 2020 Set./Dez;24(3):268-282. Disponível em: https://www.revneuropsiq.com.br/rbnp/article/view/566
Serin Y, Acar Tek N: Effect of Circadian Rhythm on Metabolic Processes and the Regulation of Energy Balance. Ann Nutr Metab 2019;74:322-330. Disponível em: https://doi.org/10.1159/000500071
Sleep influences on obesity, insulin resistance, and risk of type 2 diabetes. Reutrakul, Sirimon et al. Metabolism - Clinical and Experimental, Volume 84, 56 – 66. Disponível em: https://doi.org/10.1016/j.metabol.2018.02.010
St-Onge MP. Sleep-obesity relation: underlying mechanisms and consequences for treatment. Obes Rev. 2017 Feb;18 Suppl 1:34-39. Disponível em: https://doi.org/10.1111/obr.12499. PMID: 28164452.
Sweatt SK, Gower BA, Chieh AY, Liu Y, Li L. Sleep quality is differentially related to adiposity in adults. Psychoneuroendocrinology. 2018 Dec;98:46-51. Disponível em: https://doi.org/10.1016/j.psyneuen.2018.07.024. Epub 2018 Jul 25. PMID: 30098512; PMCID: PMC6204309.
Muscogiuri G, Barrea L, Annunziata G, Di Somma C, Laudisio D, Colao A, Savastano S. Obesity and sleep disturbance: the chicken or the egg? Crit Rev Food Sci Nutr. 2019;59(13):2158-2165. Disponível em: https://doi.org/10.1080/10408398.2018.1506979. Epub 2018 Oct 18. PMID: 30335476.
Corrêa, M M, Borges, M A de S, Oliveira, E R A. Sleep duration and overweight: is there a relationship in adolescence?. Revista Brasileira de Epidemiologia [online]. 2021, v. 24, e210031. Disponível em: https://doi.org/10.1590/1980-549720210031. Epub 28 May 2021. ISSN 1980-5497.
Touitou Y, Reinberg A, Touitou D. Association between light at night, melatonin secretion, sleep deprivation, and the internal clock: Health impacts and mechanisms of circadian disruption. Life Sci. 2017 Mar 15;173:94-106. Disponível em: https://doi.org/10.1016/j.lfs.2017.02.008. Epub 2017 Feb 16. PMID: 28214594.
Tähkämö L, Partonen T, Pesonen AK. Systematic review of light exposure impact on human circadian rhythm. Chronobiol Int. 2019 Feb;36(2):151-170. Disponível em: https://doi.org/10.1080/07420528.2018.1527773. Epub 2018 Oct 12. PMID: 30311830.
Liu Z, Gan L, Luo D, Sun C. Melatonin promotes circadian rhythm-induced proliferation through Clock/histone deacetylase 3/c-Myc interaction in mouse adipose tissue. J Pineal Res. 2017 May;62(4). Disponível em: https://doi.org/10.1111/jpi.12383. Epub 2017 Mar 21. PMID: 27987529.
Xu Z, You W, Liu J, Wang Y, Shan T. Elucidating the Regulatory Role of Melatonin in Brown, White, and Beige Adipocytes. Adv Nutr. 2020 Mar 1;11(2):447-460. Disponível em: https://doi.org/10.1093/advances/nmz070. PMID: 31355852; PMCID: PMC7442421.
Kato H, Tanaka G, Masuda S, Ogasawara J, Sakurai T, Kizaki T, Ohno H, Izawa T. Melatonin promotes adipogenesis and mitochondrial biogenesis in 3T3-L1 preadipocytes. J Pineal Res. 2015 Sep;59(2):267-75. Disponível em: https://doi.org/10.1111/jpi.12259. Epub 2015 Jul 18. PMID: 26123001.
Bueno, A; Savi, F; Alves, I; Bandeira, V. Regulatory aspects and evidences of melatonin use for sleep disorders and insomnia: an integrative review. Arq. Neuro-Psiquiatr. 79 (8) • Aug 2021 Volume 8, 732 – 742. Disponível em: https://doi.org/10.1590/0004-282x-anp-2020-0379.
Agência Nacional de Vigilância Sanitária. Atualização da lista de constituintes, de limites de uso, de alegações e de rotulagem complementar dos suplementos alimentares. Disponível em: http://antigo.anvisa.gov.br/documents/10181/6254004/Parecer+com+as+justificativas+regulat%25C3%25B3rias.pdf/9e59cb36-3b16-4be1-a7d3-4e9c6b5fb379
Agência Nacional de Vigilância Sanitária. Análise de informações sobre segurança e eficácia da melatonina. Brasília: ANVISA; junho de 2020. Disponível em: https://www.gov.br/anvisa/pt-br/assuntos/noticias-anvisa/2021/proposta-de-consulta-publica-inclui-a-melatonina-como-constituinte-autorizado/analise-da-seguranca-e-eficacia-da-melatonina_versao-para-publicacao.pdf
Xu P, Wang J, Hong F, Wang S, Jin X, Xue T, Jia L, Zhai Y. Melatonin prevents obesity through modulation of gut microbiota in mice. J Pineal Res. 2017 May;62(4). Disponível em: https://doi.org/10.1111/jpi.12399. Epub 2017 Mar 10. PMID: 28199741.
Bazyar H, Zare Javid A, Bavi Behbahani H, Moradi F, Moradi Poode B, Amiri P. Consumption of melatonin supplement improves cardiovascular disease risk factors and anthropometric indices in type 2 diabetes mellitus patients: a double-blind, randomized, placebo-controlled trial. Trials. 2021 Mar 25;22(1):231. Disponível em: https://doi.org/10.1186/s13063-021-05174-z. PMID: 33766084; PMCID: PMC7995760.
Genario R, Cipolla-Neto J, Bueno AA, Santos HO. Melatonin supplementation in the management of obesity and obesity-associated disorders: A review of physiological mechanisms and clinical applications. Pharmacol Res. 2021 Jan;163:105254. Disponível em: https://doi.org/10.1016/j.phrs.2020.105254. Epub 2020 Oct 17. PMID: 33080320.
Hope M. Foley, Amie E. Steel. Adverse events associated with oral administration of melatonin: A critical systematic review of clinical evidence. Complementary Therapies in Medicine. Volume 42, 2019, Pages 65-81, ISSN 0965-2299. Disponível em: https://doi.org/10.1016/j.ctim.2018.11.003.
Burgess HJ, Emens JS. Drugs Used in Circadian Sleep-Wake Rhythm Disturbances. Sleep Med Clin. 2018 Jun;13(2):231-241. doi: 10.1016/j.jsmc.2018.02.006. PMID: 29759273.
Zizhen Xie, Fei Chen, William A. Li, Xiaokun Geng, Changhong Li, Xiaomei Meng, Yan Feng, Wei Liu & Fengchun Yu (2017) A review of sleep disorders and melatonin, Neurological Research, 39:6, 559-565, Disponível em: https://doi.org/10.1080/01616412.2017.1315864
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