HOW THE PATHOPHYSIOLOGY OF GILBERT'S SYNDROME AFFECTS THE DAILY LIVES OF PATIENTS WITH GILBERT´'S SYNDROME: AN INTEGRATIVE REVIEW

Authors

DOI:

https://doi.org/10.47820/recima21.v5i10.5731

Keywords:

Gilbert's Syndrome, UDP-glucuroniltransferase, Syndrome

Abstract

Gilbert's Syndrome (SG) is configured as a hereditary pathology, in which a mutation occurs in the UGT1A1 gene, reducing the activity of the UDP-glucuroniltransferase enzyme, whose consequence is to change the levels of unconjugated bilirubin in the blood, generating hyperbilirubinemia. This excess of serum indirect bilirubin can lead to several clinical manifestations. Through the present study, it was observed that the symptoms can present both in a harmful and beneficial way. Among the harms, jaundice, epigastric pain and lack of energy stand out. On the other hand, cardiovascular protections and antioxidant effects characterize some of the benefits of this mutation. The diagnosis requires, in addition to complementary tests, an evaluation of serum levels of total bilirubin. It is noted that the exacerbated increase in indirect bilirubin is influenced by several factors, such as ethnicity, smoking, eating habits, genetics and sex. In addition, it is configured as a molecule with anti-inflammatory, antiatherogenic, antithrombotic and immunomodulatory effects, but an increased risk of developing diabetes mellitus, cervical and colon cancer is reported. SG is prevalent in males and does not require pharmacotherapeutic or dietary treatment, however a specialized follow-up should be carried out periodically.

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Author Biographies

Gabriel Marzola Prates

Acadêmico de Medicina do 4º semestre da Universidade Professor Edson Antônio Velano (UNIFENAS), Câmpus Alfenas.

Giovanna Marzola Prates

Acadêmica de Medicina do 6º semestre da Universidade Professor Edson Antônio Velano (UNIFENAS), Câmpus Alfenas.

Giovanna Alves Ferreira

Acadêmica de Medicina do 4º semestre da Universidade Professor Edson Antônio Velano (UNIFENAS), Câmpus Alfenas.

Isadora Zanetti Barion

Acadêmica de Medicina do 4º semestre da Universidade Professor Edson Antônio Velano (UNIFENAS), Câmpus Alfenas.

Alessandra Cristina Pupin Silvério

Professora orientadora na Universidade Professor Edson Antônio Velano (UNIFENAS), Câmpus Alfenas; doutorada em Ciências Farmacêuticas. 

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Published

09/10/2024

How to Cite

Prates, G. M., Prates, G. M., Ferreira, G. A., Barion, I. Z., & Silvério, A. C. P. (2024). HOW THE PATHOPHYSIOLOGY OF GILBERT’S SYNDROME AFFECTS THE DAILY LIVES OF PATIENTS WITH GILBERT´’S SYNDROME: AN INTEGRATIVE REVIEW. RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218, 5(10), e5105731. https://doi.org/10.47820/recima21.v5i10.5731

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